研究業績

2017年度・英文業績

Plasma epidermal growth factor receptor mutation testing with a chip-based digital PCR system in patients with advanced non-small cell lung cancer

Kasahara N, Kenmotsu H, Serizawa M, Umehara R, Ono A, Hisamatsu Y, Wakuda K, Omori S, Nakashima K, Taira T, Naito T, Murakami H, Koh Y, Mori K, Endo M, Nakajima T, Yamada M, Kusuhara M, Takahashi T.

Lung Cancer 2017;106: 138-144.

 

Amrubicin monotherapy may be an effective second-line treatment for patients with large-cell neuroendocrine carcinoma or high-grade non-small-cell neuroendocrine carcinoma

Kasahara N, Wakuda K, Omori S, Nakashima K, Ono A, Taira T, Kenmotsu H, Naito T, Murakami H, Mori K, Watanabe R, Endo M, Nakajima T, Yamada M, Takahashi T.

Molecular and Clinical Oncology 2017;6: 718-722.

 

Post-Progression Survival Associated with Overall Survival in Patients with Advanced Non-Small-Cell Lung Cancer Receiving Docetaxel Monotherapy as Second-Line Chemotherapy.

Kotake M, Miura Y, Imai H, Mori K, Sakurai R, Kaira K, Tomizawa Y, Minato K, Saito R, Hisada T.

Chemotherapy. 2017;62(4):205-213.

 

Phase I/II study of induction chemotherapy using carboplatin plus irinotecan and sequential thoracic radiotherapy (TRT) for elderly patients with limited-disease small-cell lung cancer (LD-SCLC): TORG 0604.

Misumi Y, Okamoto H, Sasaki J, Masuda N, Ishii M, Shimokawa T, Hosomi Y, Okuma Y, Nagamata M, Ogura T, Kato T, Sata M, Otani S, Takakura A, Minato K, Miura Y, Yokoyama T, Takata S, Naoki K, Watanabe K.

BMC Cancer. 2017 May 26;17(1):377.

 

Prospective exploratory study of gemcitabine and S-1 against elderly patients with advanced non-small cell lung cancer.

Kaira K, Yanagitani N, Sunaga N, Imai H, Ono A, Koga Y, Hisada T, Ishizuka T, Yamada M.

Oncol Lett. 2017 Jul;14(1):1123-1128. doi: 10.3892/ol.2017.6259. Epub 2017 May 26.

 

Prognostic effect of class III β-tubulin and Topoisomerase-II in patients with advanced thymic carcinoma who received combination chemotherapy, including taxanes or topoisomerase-II inhibitors.

Miura Y, Kaira K, Sakurai R, Imai H, Tomizawa Y, Sunaga N, Minato K, Hisada T, Oyama T, Yamada M.

Oncol Lett. 2017 Aug;14(2):2369-2378. doi: 10.3892/ol.2017.6419. Epub 2017 Jun 19.

 

Disruption of the structural and functional features of surfactant protein A byacrolein in cigarette smoke.

Takamiya R, Uchida K, Shibata T, Maeno T, Kato M, Yamaguchi Y, Ariki S,

Hasegawa Y, Saito A, Miwa S, Takahashi H, Akaike T, Kuroki Y, Takahashi M.

Sci Rep. 2017 Aug 16;7(1):8304.

 

Isoniazid-induced pure red cell aplasia in a patient with sarcoidosis, a patient summary and review of the literature Running title: Isoniazid-induced pure red cell aplasia Yasuyuki Saito, Yuri Sawada, Yasuhiko Koga, Noriaki Sunaga, Yusuke Tsukagoshi, Yoshimasa Hachisu, Takashi Osaki, Reiko Sakurai, Kyoichi Kaira, Akihiro Ono, Ken Sato, Hiromi Koiso, Junko Hirato, Tetsunari Oyama, Takeshi Hisada, Masanobu Yamada.

Intern Med. 2017 Oct 15;56(20):2753-2757.

 

High expression of GRP78/BiP as a novel predictor of favorable outcomes in patients with advanced thymic carcinoma.

Miura Y, Kaira K, Sakurai R, Imai H, Tomizawa Y, Sunaga N, Minato K, Hisada T, Oyama T, Yamada M.

Int J Clin Oncol. 2017 Oct;22(5):872-879. doi: 10.1007/s10147-017-1142-x. Epub 2017 May 26.

 

Are specialized pro-resolving mediators promising therapeutic agents for severe bronchial asthma?

Hisada T, Aoki-Saito H, Koga Y.

J Thorac Dis. 2017 Nov;9(11):4266-4269. doi: 10.21037/jtd.2017.10.116

 

Metabolic activity by 18F-FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC.

Kaira K, Higuchi T, Naruse I, Arisaka Y, Tokue A, Altan B, Suda S, Mogi A, Shimizu K, Sunaga N, Hisada T, Kitano S, Obinata H, Yokobori T, Mori K, Nishiyama M, Tsushima Y, Asao T.

Eur J Nucl Med Mol Imaging. 2018 Jan;45(1):56-66. doi: 10.1007/s00259-017-3806-1. Epub 2017 Aug 21.

 

The Onset of Eosinophilic Pneumonia Preceding Anti-synthetase Syndrome.

Hachisu Y, Koga Y, Sunaga N, Kashiwagi C, Sawada Y, Saito Y, Tsukagoshi Y, Kasahara N, Sakurai R, Tsurumaki H, Yatomi M, Kaira K, Ono A, Maeno T, Hisada T.

Intern Med. 2018 Jan 15;57(2):247-251. doi: 10.2169/internalmedicine.8955-17. Epub 2017 Nov 1.

 

A phase II study of biweekly gemcitabine and carboplatin in completely resected stage IB-IIIA non-small cell lung cancer.

Sakurai R, Tomizawa Y, Yoshii A, Miura Y, Tsurumaki H, Kaira K, Sunaga N, Kawashima O, Hisada T, Yamada M, Saito R.

Cancer Chemother Pharmacol. 2018 Jan;81(1):103-109. doi: 10.1007/s00280-017-3439-x. Epub 2017 Nov 9.

 

High expression of topoisomerase-II predicts favorable clinical outcomes in patients with relapsed small cell lung cancers receiving amrubicin.

Miura Y, Kaira K, Sakurai R, Sunaga N, Saito R, Hisada T, Yamada M.

Lung Cancer. 2018 Jan;115:42-48. doi: 10.1016/j.lungcan.2017.11.010. Epub 2017 Nov 13.

 

The effect of post-progression survival on overall survival among patients with sensitive relapse of small cell lung cancer.

Miura Y, Imai H, Sakurai R, Kaira K, Sunaga N, Minato K, Saito R, Hisada T.

Med Oncol. 2018 Mar 5;35(4):45. doi: 10.1007/s12032-018-1107-6.

 

 

 

Borrelia miyamotoi Disease Rash.

Hayashi T, Miura Y, Kawabata H.

Intern Med. 2018 Mar 30. doi: 10.2169/internalmedicine.0432-17. [Epub ahead of print]

 

2017年度・和文業績

肥満と睡眠時無呼吸症候群や呼吸障害, 肥満と疾患 どこまで解明されたか?

鶴巻寛朗, 久田剛志

2017.76-81. 上毛新聞社.

 

【アレルギーと脂質メディエーター アップデート】 レゾルビンとアレルギー

齋藤 悠[青木], 久田 剛志

アレルギー・免疫. 2018.02; 25巻3号;388-397

 

【呼吸器救急診療ブラッシュアップ-自信をもって対応できる-】主な疾患からみた救急マネージメント アナフィラキシーショック

久田 剛志

呼吸器ジャーナル. 2018.02; 66巻1号; 169-177

 

2016年度・英文業績

A randomized, open-label, phase III trial comparing amrubicin versus docetaxel in patients with previously treated non-small-cell lung cancer.
Yoshioka H, Katakami N, Okamoto H, Iwamoto Y, Seto T, Takahashi T, Sunaga N, Kudoh S, Chikamori K, Harada M, Tanaka H, Saito H, Saka H, Takeda K, Nogami N, Masuda N, Harada T, Kitagawa H, Horio H, Yamanaka T, Fukuoka M, Yamamoto N, Nakagawa K.
Ann Oncol. 2017 Feb 1;28(2):285-291

CREB regulates TNF-α-induced GM-CSF secretion via p38 MAPK in human lung fibroblasts.
Koga Y, Hisada T, Ishizuka T, Utsugi M, Ono A, Yatomi M, Kamide Y, Aoki-Saito H, Tsurumaki H, Dobashi K, Yamada M
Allergol Int. 2016, 65(4):406-413.

Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study.
Koga Y, Satoh T, Kaira K, Koka M, Hisada T, Hirato J, Altan B, Yatomi M, Ono A, Kamide Y, Shimizu Y, Aoki-Saito H, Tsurumaki H, Shimizu K, Mogi A, Ishizuka T, Yamada M, Dobashi K.
Environ Health Prev Med. Nov;21(6):492-500. 2016

Evaluation of gefitinib efficacy according to body mass index, body surface area, and body weight in patients with EGFR-mutated advanced non-small cell lung cancer.
Imai H, Kuwako T, Kaira K, Masuda T, Miura Y, Seki K, Sakurai R, Utsugi M, Shimizu K, Sunaga N, Tomizawa Y, Ishihara S, Ishizuka T, Mogi A, Hisada T, Minato K, Takise A, Saito R, Yamada M.
Cancer Chemother Pharmacol. 2017 Mar;79(3):497-505.

Phase I study of nab-paclitaxel plus carboplatin and concurrent thoracic radiotherapy in patients with locally advanced non-small cell lung cancer.
Kaira K, Tomizawa Y, Imai H, Sakurai R, Matsuura M, Yoshii A, Ochiai M, Kotake M, Ebara T, Saitoh JI, Sunaga N, Minato K, Saito R, Hisada T.
Cancer Chemother Pharmacol. 2017 Jan;79(1):165-171.

Interstitial pneumonia during administration of dipeptidyl peptidase-4 inhibitors.
Tagaya Y, Okada S, Hisada T, Niijima Y, Yamada M.
J Diabetes. 2016 May;8(3):442.

Effect of 12-month rehabilitation with low loading program on chronic respiratory disease.
Endo Y, Dobashi K, Uga D, Kato D, Nakazawa R, Sakamoto M, Fueki M, Makino S.
J Phys Ther Sci. 2016 Mar;28(3):1032-5. doi: 10.1589/jpts.28.1032. Epub 2016 Mar 31.

Associations of lifelong cigarette consumption and hypertension with airflow limitation in primary care clinic outpatients in Japan.
Utsugi H, Nakamura H, Suzuki T, Maeno T, Nagata M, Kanazawa M.
Respir Investig. 2016 Jan;54(1):35-43.

A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models.
Gao C, Fujinawa R, Yoshida T, Ueno M, Ota F, Kizuka Y, Hirayama T, Korekane H, Kitazume S, Maeno T, Ohtsubo K, Yoshida K, Yamaguchi Y, Lepenies B, Aretz J, Rademacher C, Kabata H, Hegab AE, Seeberger PH, Betsuyaku T, Kida K, Taniguchi N.
Am J Physiol Lung Cell Mol Physiol. 2017 Feb1;312(2):L268-L276.

Usefulness of 18F-α-Methyltyrosine PET as Therapeutic Monitoring of Patients with Advanced Lung Cancer.
Kaira K, Higuchi T, Sunaga N, Arisaka Y, Hisada T, Tominaga H, Oriuchi N, Asao T, Tsushima Y, Yamada M.
Anticancer Res 36; 6481-6490, 2016.

Prognostic significance of β2-adrenergic receptor expression in non-small cell lung cancer.
Yazawa T, Kaira K, Shimizu K, Shimizu A, Nagashima T, Ohtaki Y, Oyama T, MogiA, Kuwano H.
Am J Transl Res 8, 5059-5070, 2016.

Expression of ER stress markers (GRP78/BiP and PERK) in patients with tongue cancer.
Kaira K, Toyoda M, Shimizu A, Mori K, Shino M, Sakakura K, Takayasu Y, Takahashi K, Oyama T, Asao T, Chikamatsu K.
Neoplasma 63, 588-594, 2016.

Efficacy of LAT1 inhibition as a therapeutic target in esophageal squamous cell carcinoma.
Ohshima Y, Kaira K, Yamaguchi A, Oriuchi N, Tominaga H, Nagamori S, Kanai Y, Yokobori T, Miyazaki T, Asao T, Tsushima Y, Kuwano H, Ishioka NS.
Cancer Sci 107, 1499-1505, 2016.

Decreasing expression of Glucose-regulated protein GRP78/BiP as a significant prognostic predictor in patients with advanced laryngeal Squamous cell carcinoma.
Kaira K, Toyoda M, Shimizu A, Imai H, Sakakura K, Nikkuni O, Suzuki M, Iijima M, Asao T, Chikamatsu K.
Head Neck 38, 1539-1544, 2016.

Clinical significance of β2-adrenergic receptor expression in patients with surgically resected gastric adenocarcinoma.
Takahashi K, Kaira K, Shimizu A, Sat T, Tamahashi N, Ogawa H, Yoshinari D, Yokobori T, Asao T, Takeyoshi I, Oyama T.
Tumor Biology 37, 13885-13892, 2016.

Decreased expression of class III β-tubulin is associated with unfavorable prognosis in patients with malignant melanoma.
Shimizu A, Kaira K, Yasuda M, Asao T, Ishikawa O.
Melanoma Res 26, 29-34, 2016.

High Expression of MRE11-RAD50-NBS1 Is Associated with Poor Prognosis andChemoresistance in Gastric Cancer.
Altan B, Yokobori T, Ide M, Bai T, Yanoma T, Kimura A, Kogure N, Suzuki M, Bao P, Mochiki E, Ogata K, Handa T, Kaira K, Nishiyama M, Asao T, Oyama T, Kuwano.H.
Anticancer Res 36, 5237-5247, 2016.

Clinical impact of post-progression survival on overall survival in elderly patients with extensive small-cell lung cancer.
Imai H, Mori K, Watase N, Kazama T, Fujimoto S, Kaira K, Yamada M, Minato K.
Thracic Cancer 7, 655-662, 2016.

Minato. Clinical aignificance of the relationship between progression-free survival or postprogression survival and overall survival in patients with extensive disease-small-cell lung cancer treated with carboplatin plus etoposide.
Imai H, Mori K, Watase N, Fujimoto S, Kaira K, Yamada M,
Can Resp J 2016, 5405810, 2016.

Relationship between tumor-associated macrophage subsets and CD147 expression in squamous cell carcinoma of the head and neck in the tumor microenviroment.
Sakakura K, Takahashi H, Kaira K, Toyoda M, Murata T, Ohnishi H, Oyama T,
Chikamatsu K.Lab Invest 96, 994-1003, 2016.

Prognostic potent of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma.
Enokida Y, Shimizu K, Atsumi J, Kakegawa S, Takase Y, Kaira K, Yashima H, Nakazawa S, Ohtaki Y, Nagashima T, Lezhava A, Usui K, Ishikawa T, Hayashizaki Y,
Takeyoshi I. Cancer Med 5, 1791-1801, 2016.

Risk factors associated with recurrence of surgically resected node-positive non-small cell lung cancer.
Ohtaki Y, Shimizu K, Kaira K, Nagashima T, Obayashi K, Nakazawa S, Kakegawa S, Igai H, Kamiyoshihara M, Nishiyama M, Takeyoshi I.
Surg Today 46, 1196-1208, 2016.

Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging.
Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Oriuchi N, Nagamori S, Kanai Y.
Cancer Sci 107, 347-352, 2016.

Transport of 3-fluoro-l-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [18F]FAMT positron emission tomography.
Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Kato Y, Oriuchi N, Nagamori S, Kanai Y.
J Pharmacol Sci 130, 101-109, 2016.

Prognostic significance of GRP78/BiP expression in patients with stage III/IV hypopharyngeal squamous cell carcinoma.
Kaira K, Toyoda M, Shimizu A, Imai H, Sakura K, Nikkuni, Suzuki M, Iijima M, Asao T, Chikamatsu K.
Neoplasma 63, 477-483, 2016.

Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma.
Honjo H, Kaira K, Miyazaki T, Yokobori T, Kanai Y, Nagamori S, Oyama T, Asao T, Kuwano H.
J Surg Oncol 113, 381-389, 2016.

Prognostic significance of β2-adrenergic receptor expression in malignant melanoma.
Shimizu A, Kaira K, Mori K, Kato M, Shimizu K, Yasuda M, Takahashi A, Oyama T, Asao T, Ishikawa O.
Tumor Biology 37, 5971-5978, 2016.

Prognostic significance of thymidylate synthase (TS) expression in cutaneous malignant melanoma.
Shimizu A, Kaira K, Yasuda M, Asao T, Ishikawa O.
Neoplasms 63, 282-287, 2016.

Decreased expression of class III β-tubulin is associated with unfavorable prognosis in patients with malignant melanoma.
Shimizu A, Kaira K, Yasuda M, Asao T, Ishikawa O.
Melanoma Res 26, 29-34, 2016.

Expression of ER stress markers (GRP78/BiP and PERK) in adenoid cystic carcinoma.
Kaira K, Toyoda M, Shimizu A, Shino M, Sakakura K, Takayasu Y, Takahashi K, Asao T, Chikamatsu K.
Acta Oto-laryngologica 136, 1-7, 2016.

Prognostic significance of aromatase and estrogen receptor beta expression in EGFR wild-type lung adenocarcinoma.
Tanaka K, Shimizu K, Kakegawa S, Ohtaki Y, Nagashima T, Kaira K, Horiguchi J, Oyama T, Takeyoshi I.
Am J Transl Res 8, 81-97, 2016.

Phase I dose escalation study of amrubicin plus paclitaxel in previously treated advanced non-small cell lung cancer.
Kaira K, Sunaga N, Imai H, Kamide Y, koga Y, Ono A, Kuwako T, Masuda T, Hisada T Ishizuka T , Yamada M.
Int J Clin Oncol 21, 240-247, 2016.

Comparison of the efficacy of radiotherapy between postoperative mediastinal lymph node recurrence and stage III disease in non-small cell lung cancer patients.
Imai H, Murakami H, Yoshino R, Mori K, Sumita K, Ono A, Akamatsu H, Taira T, Kenmotsu H, Harada H, Naito T, Kaira K, Tomizawa Y, Ohde Y, Matsuura M, Endo M, Saito R, Nakajima T, Takahashi T
J BUON 21, 333-340, 2016

Keratotic condyloma acuminatum.
Shimizu A, Hattori M, Kaira K, Ishikawa O.
J Dermatol. 43, 716-717, 2016.

 

2016年度・和文業績

職業性アレルギー疾患診療ガイドライン2016, 職業性アレルギー疾患診療ガイドラインガイドライン2016作成委員会編,協和企画出版.(2016)

アスベスト関連肺腫瘍における吸入分子分布とp116Ripの発現解析について.
古賀康彦. vol.6 No.1. BIO CLINICA.北隆館. 2017. 142-145.

ビスホスフォネート薬によるCOPDの症状緩和について
上野学、前野敏孝、倉林正彦
感染・炎症・免疫 2016;46(2):79-82

Sjogren症候群に合併した気管支原発MALTリンパ腫の一例
鈴木雅文、原健一郎、前野敏孝
日本呼吸器学会誌 2016;5(4):213-216

COPD患者におけるチオトロピウム・インダカテロール併用からグルコピロニウム/インダカテロール配合剤への変更による効果
宇津木 光克、松崎 晋一、蜂巣 克昌、矢冨 正清、久田 剛志、山田 正信、土橋 邦生、丸田 栄
日本呼吸ケア・リハビリテーション学会誌 26(1), 73-77, 2016

 

2015年度・英文業績

Epiregulin as a therapeutic target in non-small-cell lung cancer.
Sunaga N, Kaira K.
Lung Cancer (Auckl). 2015 Oct 12;6:91-98.

Protective Role of Proton-Sensing TDAG8 in Lipopolysaccharide-Induced Acute Lung Injury.
Tsurumaki H, Mogi C, Aoki-Saito H, Tobo M, Kamide Y, Yatomi M, Sato K, Dobashi K, Ishizuka T, Hisada T, Yamada M, Okajima F
Int J Mol Sci. 2015;16(12):28931-42.

17(R)-resolvin D1 ameliorates bleomycin-induced pulmonary fibrosis in mice.
Yatomi M, Hisada T, Ishizuka T, Koga Y, Ono A, Kamide Y, Seki K, Aoki-Saito H, Tsurumaki H, Sunaga N, Kaira K, Dobashi K, Yamada M, Okajima F
Physiol Rep. 2015, 3(12). pii: e12628.

Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells.
Kamide Y, Ishizuka T, Tobo M, Tsurumaki H, Aoki H, Mogi C, Nakakura T, Yatomi M, Ono A, Koga Y, Sato K, Hisada T, Dobashi K, Yamada M, Okajima F
Biochem Biophys Res Commun. 2015, 464(3):949-55.

Clinical impact of post-progression survival on overall survival in patients with limited-stage disease small cell lung cancer after first-line chemoradiotherapy.
Kasahara N, Imai H, Kaira K, Mori K, Wakuda K, Ono A, Taira T, Kenmotsu H, Harada H, Naito T, Murakami H, Endo M, Nakajima T, Yamada M, Takahashi T.
Radiol Oncol. 2015 Nov 27;49(4):409-15.

Comparison of the efficacy of radiotherapy between postoperative mediastinal lymph node recurrence and stage III disease in non-small cell lung cancer patients.
Imai H, Murakami H, Yoshino R, Mori K, Sumita K, Ono A, Akamatsu H, Taira T, Kenmotsu H, Harada H, Naito T, Kaira K, Tomizawa Y, Ohde Y, Matsuura M, Endo M, Saito R, Nakajima T, Takahashi T.
J BUON. 2016 Mar-Apr;21(2):333-40.

First-line gefitinib treatment in elderly patients (aged ≥75 years) with non-small cell lung cancer harboring EGFR mutations.
Kuwako T, Imai H, Masuda T, Miura Y, Seki K, Yoshino R, Kaira K, Utsugi M, Shimizu K, Sunaga N, Tomizawa Y, Ishihara S, Ishizuka T, Mogi A, Hisada T, Minato K, Takise A, Saito R, Yamada M.
Cancer Chemother Pharmacol. 2015 Oct;76(4):761-9.

Pulmonary Aluminosis Diagnosed with In-air Microparticle Induced X-ray Emission Analysis of Particles.Chino H, Hagiwara E, Sugisaki M, Baba T, Koga Y, Hisada T, Kaira K, Okudela K, Takemura T, Dobashi K, Ogura T.
Intern Med. 2015;54(16):2035-40.

Effects of early physiotherapy with respect to severity of pneumonia of elderly patients admitted to an intensive care unit: a single center study in Japan.
Chigira Y, Takai T, Igusa H, Dobashi K.
J Phys Ther Sci. 2015 Jul;27(7):2053-6. doi: 10.1589/jpts.27.2053. Epub 2015 Jul 22.

Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis.
Shimizu Y, Dobashi K, Nagase H, Ohta K, Sano T, Matsuzaki S, Ishii Y, Satoh T, Koka M, Yokoyama A, Ohkubo T, Ishii Y, Kamiya T.
J Clin Biochem Nutr. 2015 Jan;56(1):74-83. doi: 10.3164/jcbn.14-44. Epub 2014 Nov 28.

A case of Trousseau syndrome caused by pulmonary adenocarcinoma that was controlled for one year and 10 months with thrombosis treatment using an EGFR tyrosine kinase inhibitor and chemotherapy.
Masubuchi H, Maeno T, Uchida M, Kono S, Suzuki M, Takemura M, Yamaguchi A, Yamaguchi K, Kanbe M, Kitahara S, Hara K, Hara S, Aoki N, Suga T, Kurabayashi M.
Respir Med Case Rep. 2015 May 23;15:101-5.

A case of anti-MDA5-positive rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis ameliorated by rituximab, in addition to standard immunosuppressive treatment.
Yamaguchi K, Yamaguchi A, Uchida M, Kono S, Suzuki M, Masubuchi H, Kitahara S, Ueno M, Hara K, Aoki F, Aoki N, Maeno T, Masayoshi Y, Chikako K, Yoshinao M, Suga T, Kurabayashi M.
Mod Rheumatol. Epub 2015 Mar 12.

Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages.
Ueno M, Maeno T, Nishimura S, Ogata F, Masubuchi H, Hara K, Yamaguchi K, Aoki F, Suga T, Nagai R, Kurabayashi M.
Nat Commun. 2015 Mar 10;6:6332. doi: 10.1038/ncomms7332.

B cells play key roles in th2-type airway immune responses in mice exposed to natural airborne allergens.
Drake LY, Iijima K, Hara K, Kobayashi T, Kephart GM, Kita H.
PLoS One. 2015 Mar 24;10(3):e0121660.

Clinical significance of coexpression of L-type amino acid transporter 1 (LAT1) and ASC amino acid transporter 2 (ASCT2) in lung adenocarcinoma.
Yazawa T, Shimizu K, Kaira K, Nagashima T, Ohtaki Y, Atsumi J, Obayashi K, Nagamori S, Kanai Y, Oyama T, Takeyoshi I.
Am J Transl Res 7, 1126-1139, 2015.

Prognostic significance of diabetes mellitus in locally advanced non-small cell lung cancer.
Imai H, Kaira K, Mori K, Ono A, Akamatsu H, Matsumoto S, Taira T, Kenmotsu H, Harada H, Naito T, Murakami H, Endo M, Nakajima T, Yamada M, Takahashi T.
BMC Cancer 15, 989, 2015

Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in patients with ovarian tumors.
Kaira K, Nakamura K, Hirakawa T, Imai H, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Tsukamoto N, Oyama T, Asao T, Minegishi T.
Am J Transl Res 7, 1161-1171, 2015.

Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma.
Shimizu A, Kaira K, Kato M, Yasuda M, Takahashi A, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Asao T, Ishikawa O.
Melanoma Res 25, 399-405, 2015.

Expression of amino acid transporters (LAT1 and ASCT2) in patients with stage III/IV laryngeal squamous cell carcinoma.
Nikkuni O, Kaira K, Toyoda M, Shino M, Sakakura M, Takahashi K, Tominaga H, Oriuchi N, Suzuki M, Iijima M, Asao T, Nishiyama M, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
Pathol Oncol Res 21, 1175-1181, 2015.

The efficacy of amrubicin on central nervous system metastases originating from small-cell lung cancer: a case series of eight patients.
Miura S, Kaira K, Kaira R, Akamatsu H, Ono A, Shukuya T, Tsuya A, Nakamura Y, Kenmotsu H, Naito T, Murakami H, Takahashi T, Endo M, Yamamoto N.
Invest New Drugs 33, 755-760, 2015.

Comparison of platinum combination re-challenge therapy and docetaxel monotherapy in non-small cell lung cancer patients previously treated with platinum-based chemoradiotherapy.
Imai H, Kaira K, Mori K, Ono A, Akamatsu H, Taira T, Yoshino R, Kenmotsu H, Saitoh J, Harada H, Naito T, Murakami H, Tomizawa Y, Matsuura M, Saito R, Nakajima T, Yamada M, Takahashi T.
Springerplus. 31, 4, 152, 2015.

Relationship between CD147 and expression of amino acid transporters (LAT1 and ASCT2) in patients with pancreatic cancer.
Kaira K, Arakawa K, Shimizu K, Oriuchi N, Nagamori S, Kanai, Oyama T, Takeyoshi I. Progression-free survival, post-progression survival, and tumor response as surrogate markers for overall survival in patients with extensive small cell lung cancer.
Imai H, Mori K, Wakuda K, Ono A, Akamatsu H, Shukuya T, Taira T, Kenmotsu H, Naito T, Kaira K, Murakami H, Endo M, Nakajima T, Yamamoto N, Takahashi T.
Ann Thorac Med 10, 61-66, 2015.

CD98 is a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma.
Toyoda M, Kaira K, Shino M, Sakakura K, Takahashi K, Takayasu Y, Tominaga H, Oriuchi N, Nikkuni O, Suzuki M, Iijima M, Tsukamoto N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
Head Neck 37, 1569-1574, 2015.

Clinicopathological Significance of ASC-Amino Acid Transporter 2 (ASCT2) Expression in Pancreatic Ductal Carcinoma.
Kaira K, Sunose Y, Arakawa K, Sunaga N, Shimizu K, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Takeyoshi I.
Histopathology 66, 234-243, 2015.

Progression-free survival, post-progression survival, and tumor response as surrogate markers for overall survival in patients with extensive small cell lung cancer.
Imai H, Mori K, Wakuda K, Ono A, Akamatsu H, Shukuya T, Taira T, Kenmotsu H, Naito T, Kaira K, Murakami H, Endo M, Nakajima T, Yamamoto N, Takahashi T.
Ann Thorac Med 10, 61-66, 2015.

An Autosomal Recessive Mutation of DSG4 Causes Monilethrix through the ER Stress Response.
Kato M, Shimizu A, Yokoyama Y, Kaira K, Shimomura Y, Ishida-Yamamoto A, Kamei K, Tokunaga F, Ishikawa O.
J Invest Dermatol 135, 1253-1260, 2015.

Prognostic impact of cancer cachexia in patients with advanced non-small cell lung cancer.
Kimura M, Naito T, Kenmotsu H, Taira T, Wakuda K, Oyakawa T, Hisamatsu Y, Tokito T, Imai H, Akamatsu H, Ono A, Kaira K, Murakami H, Endo M, Mori K, Takahashi T, Yamamoto N.
Support Care Cancer 23, 1699-1708, 2015.

Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.
Sakakura K, Takahashi H, Kaira K, Toyoda M, Oyama T, Chikamatsu K.
Cancer Sci 106, 1-8, 2015

Efficacy of platinum combination chemotherapy after first-line gefitinib treatment in non-small cell lung cancer patients harboring EGFR mutations.
Masuda T, Imai H, Kuwako T, Miura Y, Yoshino R, Kaira K, Shimizu K, Sunaga N, Tomizawa Y, Ishihara S, Mogi A, Hisada T, Minato Km Takise A, Saito R, Yamada M:
Clin Transl Oncol 17, 702-709, 2015.

18F-FDG uptake on PET correlates with biological potential in early oral squamous cell carcinoma.
Yokobori Y, Toyoda M, Sakura K, Kaira K, Tsushima Y, Chikamatsu K.
Acta Oto-laryngologica 135, 494-499, 2015.

Expression of amino acid transporters (LAT1, ASCT2 and xCT) as clinical significance in hepatocellular carcinoma.
Namikawa M, Kakizaki S, Kaira K, Tojima H, Yamazaki Y, Horiguchi N, Sato K, Oriuchi N, Tominaga H, Sunose Y, Nagamori S, Kanai Y, Oyama T, Takeyoshi I, Yamada M. Hepatol Res 45, 1014-1022, 2015.

Hydroxyurea-induced Pneumonitis in a Patient with Chronic Myelomonocytic Leukemia.
Imai H, Matsumura N, Yamazaki Y, Kanayama Y, Masuda T, Kuwako T, Kamide Y, Tomizawa T, Matsumoto S, Mitsui T, Kaira K, Ono A, Koga Y, Shibusawa N, Sunaga N, Hisada T, Yokoo H, Yamada M.
An Autopsy Case. Intern Med. 54, 3171-3176, 2015.

Pulmonary Aluminosis Diagnosed with In-air Microparticle Induced X-ray Emission Analysis of Particles.
Chino H, Hagiwara E, Sugisaki M, Baba T, Koga Y, Hisada T, Kaira K, Okudela K, Takemura T, Dobashi K, Ogura T.
Intern Med. 54, :2035-2040, 2015.

Recurrent intimal sarcoma mimicking pulmonary embolism.
Kaira K, Imai H, Yamada M.
Jpn J Clin Oncol. 45, 695-6, 2015.

Anaplastic Lymphoma Kinase (ALK) Rearrangement-positive Lung Cancer with Transformation to Pleomorphic Carcinoma.
Kamide Y, Kaira K, Watanabe T, Kuribayashi S, Ozawa A, Koga Y, Ono A, Sunaga N, Hisada T, Oyama T, Yamada M.
Intern Med. 54, 2905-2909, 2015.

 

2015年度・和文業績

気管支喘息におけるプロトン感知性G蛋白共役型受容体OGR1ファミリーの役割
齋藤(青木) 悠, 岡島 史和 医学書院
呼吸と循環 63巻 10号, pp. 915–920

特集/「長引く咳への対応~成人・小児~」に寄せる
気管支喘息モデルにおけるプロトン感知性受容体
OGR1の役割
齋藤(青木) 悠, 岡島 史和
北隆社 2015年6月号

MostGraph-01にて測定した呼吸インピーダンスに対する肥満の影響
磯部全、原健一郎、前野敏孝
アレルギー. 2015, 64(9); 1254-1260

ビスホスホネート製剤吸入による肺胞マクロファージの抑制作用とCOPD治療の試み
上野学,前野敏孝,倉林正彦
THE LUNG-perspectives 23巻4号 Page414-419(2015.11)